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Home » Recipes » Dinner

Melt-In-Your-Mouth Chicken Breasts

Published: Jul 10, 2025 by Janet · This post may contain affiliate links · Leave a Comment

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Why You’ll Love This Recipe

Melt-In-Your-Mouth Chicken Breasts are incredibly tender and moist, thanks to the rich mayonnaise (or Greek yogurt) coating. The addition of freshly grated Parmesan cheese gives the chicken a deliciously savory flavor that pairs beautifully with the subtle seasoning of garlic powder, black pepper, and seasoning salt. It's quick to prepare, requires minimal ingredients, and can be easily customized with herbs or spices to suit your preferences. If you're looking for a simple, fuss-free dish that never compromises on flavor, this recipe is for you!

Ingredients

  • 4 boneless chicken breast halves

  • 1 cup mayonnaise or 1 cup Greek yogurt

  • 1⁄2 cup parmesan cheese, freshly grated

  • 1⁄2 teaspoon seasoning salt

  • 1⁄2 teaspoon ground black pepper

  • 1 teaspoon garlic powder

(Tip: You'll find the full list of ingredients and measurements in the recipe card below.)

Directions

  1. Preheat your oven to 375°F (190°C). Grease a baking dish or line it with parchment paper for easy cleanup.

  2. In a medium bowl, combine the mayonnaise (or Greek yogurt), Parmesan cheese, seasoning salt, black pepper, and garlic powder. Stir until well-mixed.

  3. Place the chicken breasts into the prepared baking dish.

  4. Spread the mayonnaise mixture evenly over the top of each chicken breast.

  5. Bake for 40-45 minutes, or until the chicken reaches an internal temperature of 165°F (75°C) and is golden brown on top.

  6. Remove from the oven and let the chicken rest for a few minutes before serving.

Servings and Timing

  • Servings: 4

  • Total Time: 55 minutes (including prep and bake time)

Variations

  • Herb-Infused: Add fresh or dried herbs like thyme, rosemary, or basil to the mayonnaise mixture for a more aromatic flavor profile.

  • Spicy Kick: Stir in a bit of hot sauce, chili powder, or cayenne pepper to give the chicken a spicy twist.

  • Cheese Varieties: Swap out the Parmesan for other cheeses, such as mozzarella or cheddar, to suit your preferences.

  • Greek Yogurt Option: For a lighter version, use Greek yogurt instead of mayonnaise. It will still yield a moist and tender chicken, with a slightly tangy flavor.

Storage/Reheating

  • Storage: Store leftover chicken in an airtight container in the refrigerator for up to 3-4 days.

  • Reheating: To reheat, place the chicken in the oven at 350°F (175°C) for about 10-15 minutes, or until heated through. Alternatively, you can reheat it in the microwave, but it may not stay as crispy.

FAQs

1. Can I use chicken thighs instead of breasts?

Yes, chicken thighs would work well with this recipe, though they may require a slightly longer cooking time due to their higher fat content.

2. Can I make this recipe ahead of time?

Yes, you can prep the chicken and refrigerate it with the mayonnaise mixture on top for up to 24 hours before baking.

3. Can I use a different type of cheese?

Absolutely! If you prefer another cheese, feel free to swap Parmesan for mozzarella, cheddar, or even Gouda for a unique flavor.

4. How do I know when the chicken is cooked through?

The chicken is fully cooked when the internal temperature reaches 165°F (75°C). You can use a meat thermometer to check.

5. Can I freeze this recipe?

Yes, you can freeze the chicken breasts before or after baking. To freeze before baking, wrap them tightly in plastic wrap and aluminum foil. To freeze after baking, store the chicken in an airtight container.

6. Can I make this recipe without mayonnaise?

Yes, Greek yogurt can be used as a substitute for mayonnaise. It will still result in a creamy, moist chicken.

7. Can I add vegetables to this dish?

Yes, you can add vegetables to the baking dish, such as carrots, potatoes, or green beans. Just make sure to adjust the cooking time as needed.

8. Can I make this recipe in an air fryer?

Yes, you can cook the chicken breasts in an air fryer at 375°F (190°C) for 20-25 minutes, depending on the size of the chicken breasts.

9. Can I use a pre-made seasoning blend instead of individual spices?

Absolutely! A store-bought seasoning blend like Italian seasoning or poultry seasoning can be used in place of the garlic powder, black pepper, and seasoning salt.

10. Is this recipe gluten-free?

Yes, this recipe is naturally gluten-free as long as you use gluten-free mayonnaise or Greek yogurt and ensure your Parmesan is gluten-free.

Conclusion

Melt-In-Your-Mouth Chicken Breasts are the perfect combination of simplicity and flavor. With just a few ingredients, you can create a delicious, tender chicken dish that’s sure to impress. Whether you’re cooking for your family or guests, this recipe will quickly become a go-to meal. Its versatility allows for easy adaptations, and it pairs well with almost any side dish. Try it today and enjoy a meal that’s both comforting and full of flavor!

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Melt-In-Your-Mouth Chicken Breasts

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A simple yet flavorful recipe for juicy, melt-in-your-mouth chicken breasts coated in mayonnaise (or Greek yogurt) and Parmesan cheese. The creamy mixture locks in moisture, while the savory cheese gives it an irresistible flavor.

  • Author: Janet
  • Prep Time: 10 minutes
  • Cook Time: 40-45 minutes
  • Total Time: 55 minutes
  • Yield: 4 servings
  • Category: Main Course
  • Method: Baking
  • Cuisine: American
  • Diet: Gluten Free

Ingredients

4 boneless chicken breast halves

1 cup mayonnaise or Greek yogurt

½ cup freshly grated Parmesan cheese

½ teaspoon seasoning salt

½ teaspoon ground black pepper

1 teaspoon garlic powder

Instructions

  1. Preheat your oven to 375°F (190°C). Grease a baking dish or line it with parchment paper for easy cleanup.
  2. In a medium bowl, combine the mayonnaise (or Greek yogurt), Parmesan cheese, seasoning salt, black pepper, and garlic powder. Stir until well-mixed.
  3. Place the chicken breasts into the prepared baking dish.
  4. Spread the mayonnaise mixture evenly over the top of each chicken breast.
  5. Bake for 40-45 minutes, or until the chicken reaches an internal temperature of 165°F (75°C) and is golden brown on top.
  6. Remove from the oven and let the chicken rest for a few minutes before serving.

Notes

  • You can substitute Greek yogurt for mayonnaise for a lighter version.
  • Add herbs like thyme or rosemary to the mayonnaise mixture for extra flavor.
  • For a spicy twist, add hot sauce or chili powder to the mixture.
  • Chicken thighs can be used instead of breasts, though they may require a longer cooking time.
  • Store leftovers in an airtight container in the refrigerator for up to 3-4 days.

Nutrition

  • Serving Size: 1 chicken breast
  • Calories: 350
  • Sugar: 1g
  • Sodium: 650mg
  • Fat: 26g
  • Saturated Fat: 4g
  • Unsaturated Fat: 20g
  • Trans Fat: 0g
  • Carbohydrates: 2g
  • Fiber: 0g
  • Protein: 30g
  • Cholesterol: 90mg

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Hi, I’m Janet! Welcome to Recipes by Janet, where I share simple, delicious, and reliable recipes for every meal.

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